News

1-Egyptian – French research projects supported by the French Ministry of Foreign Affairs and the Egyptian Academy of Scientific Research

(Imhotep -Hubert Curien project)

Analysis of Cofactors Associated with Progression of Fibrosis and Hepatocellular Carcinoma in untreated Egyptian Patients affected by chronic Hepatitis C

Investigateur Principal cote Francaise : Prof Patrick Marcellin

Investigateur Principal cote Egyptienne: Prof Ahmed El Ray

First project is completed with the publication of these results:

  The second project:

Validity of a New Histopathological Algorithm and Scoring system for Evaluation  of Liver Lesions in Egyptian  Patients  with Chronic HCV ;Correlation with Insulin Resistance and Metabolic Syndrome

 Principal Investigator French side: Prof Valerie Paradis

 Egyptian Principal Investigator: Prof. Ahmed El Ray.

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Research published in international journals:

Research published in cooperation with the different departments of the Beaujon Hospital and Theodor Bilharz Institute.

Services concerned: Hepatology, Pathology and Microbiology Department

(Beaujon Hospital) and Hepatogastroenterology Department, Clinical Biochemistry Department, Molecular Biology Department, Microbiology Department of the Bilharz Institute.

Ø Insulin resistance: a major factor associated with significant liver fibrosis in Egyptian patients with genotype 4 chronic hepatitis C. El Ray A, Asselah T, Moucari R, El Ghannam M, Taha AA, Saber MA, Akl M, Atta R, Shemis M , Radwan AS, Ghali A, Paradise V, Marcellin P.Eur J Gastroenterol Hepatol. 2013 Apr; 25 (4): 421-7

Ø Ass IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C Asselah T1, De Muynck S, Broet P, Masliah-Planchon J, Blanluet M, Bièche I, Lapalus M, Martinot-Peignoux M, Lada O, Estrabaud E , Zhang Q, El Ray A, Vidaud D, Ripault MP, Boyer N, Bedossa P, Valla D, Vidaud M, Marcellin P. IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C. J Hepatol. 2012 Mar; 56 (3): 527-32.

Ø Faecal carriage of extended -spectrum β-lactamase (ESBL) -producing Enterobacteria in liver disease patients from two hospitals in Egypt and in France: a comparative epidemiologic study. N. Fam, Defasque, F. Bert, V leflon-Gibout A. El-Ray, M. El Ghanam, M. E. Atia, M. Omar, D. G. Desouki, Valla. And M-H. Nicolas-Chanone. Epidemiology and infection (2014); 7: 1-9

Ø Es CTX-M-15-producing Escherichia coli clinical isolates in Cairo (Egypt), including isolates of clonal complex ST10 and clones ST131, ST73 and ST405 in both community and hospital settings.Fam N, Leflon-Guibout V, Fouad S, Aboul-Fadl L, Marcon E, Desouky D, El-Defrawy I, Abou-Aitta A, Klena J and Nicolas-Chanoine M-H. Micob Drug Resist 2011; Vol 17: 67-73

Ø Patients -High predictive value of early viral kinetics in retreatment with peg interferon and ribavirin of chronic hepatitis C patients not responding to standard combination therapy. Moucari R, Ripault MP, Oulès V, Martinot-Peignoux M, Asselah T, Boyer N, El Ray A, Cazals-Hatem D, Vidaud D, Valla D, Bourlière M, Marcellin P. J Hepatol. 2007 Apr; 46 (4): 596-604.

Ø Twelve weeks post treatment follow-up of the patient with C-reactive virus, pegylated interferon and ribavirin .Martinot-Peignoux M, Stern C, Maylin S, Ripault MP, Boyer N, Leclere L, Castelnau C, Giuily N, El Ray A, Cardoso AC, Moucari R, Asselah T, Marcellin P. Hepatology. 2010 Apr; 51 (4): 1122-6.

Ø Fibrosis in Chronic Hepatitis C: Correlation between Immunohistochemically-Assessed Virus Load with Steatosis and Cellular Iron Content.Akl M, Hindawi AE, Mosaad M, Montasser A, Ray AE, Khalil H, Anas A, Atta R, Paradise V, Hadi AA , Hammam O.Open Access Maced J Med Sci. 2016 Dec 15; 4 (4): 578-584. doi: 10.3889 / oamjms.2016.122.

Training for doctors of Theodor Bilharz Research Institute

1- Dr. Hani Ezzat (Resident Doctor at Hepatogastroenterology, TBRI) had a training in the hepatology department at the Beaujon Hospital (January-February 2016) - under the direction of Prof. Durand.

2-Dr. Iris Nessim (Professor of Clinical Chemistry, TBRI) had training in Clinical Biochemistry under the direction of Prof. Katell Peoc'h- October 2016.

3-Dr. Ahmed Montasser (Master at the service of Anapat TBRI) had Three training courses at the service of Pathology Dpt  under the direction of Prof. Valerie Paradis (6-27 July

2015- 16-30 November 2017 and a 9 months training 2018-2019)

4-Dr. Nevine Fam  had training in Microbiology under the direction of Prof. Nicolas Chanoine - March 2015.

5-Dr. Raafat Atta (assistant professor in the hepatogastroenterology department, TBRI) had  training  in the Department of GI Endoscopy  from 6 to 13 June 2016 under the supervision of Dr. Maxime Palazzo.

6-Dr. Mohamed Shemis, Assistant Professor in the Molecular Biology Department had training in the hepatology department under the supervision of Prof. Marcellin from 7-17 September 2015.

7-Dr. Mohamed hossny Abdel Maksoud: Internship at the Department of Radiology at the Beaujon Hospital  was trained on April 2015 under the supervision of Prof Valerie Vilgrain.

8-Dr. Eman El Ahwany Assistant Professor in the Immunology Department

TBRI: had training in the Department of Hepatology under the direction of Prof Marcellin 2015.

9-Dr Reham Said Stage (Master at the Department of Anesthesiology, TBRI) had training in the department of Anasthesia - Reanimation under the direction of Prof Catherine - Paugam - Burtz 4- 18 september 2015.

10-Dr. Ahmed Gamal Darwish: Master in Hepatogastroenterology TBRI had training at the endoscopy department of the Beaujon Hospital from April 19th to May 9th 2015.

11-Dr Hani Ezzat, Master in Hepatogastroenterology TBRI had training at the

Hepatology department of the Beaujon Hospital in  January 2016.

12-Dr Mohamed Lasheen,  Master in Hepatogastroenterology TBRI had training at the Hepatology department of the Beaujon Hospital from  (July – August 2017).

13-Dr Mohamed Dwidar, Master in Hepatogastroenterology TBRI had training at the Hepatology department of the Beaujon Hospital from (1-15 November 2017)

14-Dr Mohamed Abdel Moneim Reda, Master in Hepatogastroenterology TBRI had training at the Hepatology department of the Beaujon Hospital (15-30 November 2017)

15-Dr. Khaled Ragab  (Lecturer in the hepatogastroenterology department TBRI) had Training  in the Department of GI Endoscopy  from November 2018 under the supervision of Dr. Maxime Palazzo.

First Seminar : Pathology in cooperation with the Beaujon Hospital, the seminar was conducted at Theodor Bilharz Research Institute  (December 2015)

Dr. Nicolas Potè presented the subject:

"Biomarkers of microvascular invasion in hepatocellular carcinoma".

Dr. Ahmed Youssef of Anapath Service at TBRI presented the subject:

"NASH: Clinicopathological Correlation

The Annual Scientific Meeting in Hepatogastroenteolgy  in Cairo .

This Annual conferences have become very famous in the field of Hepatogastroenterology in Egypt and are expected by all hepatogastroenterologists.

The First conference : Beaujon - Bilharz 2007: with the participation of Prof. Philippe Ruszniewski  - Prof Valerie Paradis  and  Prof Tarik Asselah.

The second conference: Bilharz – Beaujon 2008 with the participation of Prof. Ruszniweski, Prof. Dominique Valla,  Prof .Valerie Vilgrain  and  Prof. Chanoine.

The Third conference: Bilharz – Beaujon 2009 with the participation of Prof. Ruszniweski, Prof. Patrick Marcellin  and Prof. Jean Mantz.

The  Fourth conference Bilharz – Beaujon 2010  with the participation of Prof.

Philippe Ruszniewski, Prof. Patrick Marcellin, Prof. Francois Durand and Prof. Olivier Farges.

The Fifth Annual Scientific meeting between Beaujon Hospital and Theodor Bilharz in May 2011   with the participation of Prof. Philippe Rusznieski, Professor Patrick Marcellin, Dr. Olivier Corcosm, and  Dr Richard Moreau.

The sixth conference: Beaujon - Bilharz 2012: with the participation of Prof. Patrick Marcelin - Prof. Valérie Paradis - Dr. Maxime Palazo, The conference was inaugurated by Mrs. Nadia Zakhari the Minister of Scientific Research.

The seventh Beaujon - Bilharz Conference 2015 with the participation of Prof. Ruszniewski, Prof. Valérie Paradis, Prof. Pierre Emmanuelle Rautou, the conference was inaugurated by the Minister of Scientific Research Prof. Sherif Hammad.

 The eighth Beaujon Bilharz Conference 2016 with the participation of Prof. François Durand, Prof. Valérie Paradis and Dr. Safi Dokmak.

The Ninth Beaujon Bilharz 2017 Conference with the participation of Prof. Philippe

Ruszniewski, Dr. Richard Moreau, Prof. Rautou, Prof. Pierre Bedossa and Prof Xavier Treton.

The Tenth Beaujon Bilharz 2018 Conference with the participation of Prof. Philippe Ruszniewski, Prof. Patrick Marcellin, Prof. Valerie Paradis, Dr Laurent Palazzo . The conference

was associated for the first time with a workshop in Endosonography  performed in TBRI and received 6  continuous medical education points (CME points) from the European Accreditation council for CME credits. The conference was inaugurated by his excellency Monsieur Romatet the French Ambassador in Egypt.

The Eleventh Beaujon Bilharz 2019 Conference  was held with the participation  of Prof. Philippe Ruszniewski, Prof. Patrick Marcellin ,  Prof. Philippe Levy, Prof. Valerie Paradis and Prof. Soubane.

The twelfth Conference on hepatogastrontrology diseases 2023: it was organized by TBRI, Faculty of Medicine, Cairo University, Beaujon Hospital, and Paris Cite University, with the attendance of The French Ambassador to Egypt, his Excellency Mr. Eric Chevallier.    

Installation of new units and new techniques at the Bilharz Institute thanks to the cooperation Beaujon - Bilharz

Installation of the Fibroscan unit at TBRI:

 In collaboration with Dr. Laurent Castera of the Hepatology Department of the Beaujon Hospital, TBRI has chosen and purchased the Fibroscan device used for the diagnosis of liver fibrosis, the work has already started in November 2016 with the implementation to carry out research projects with the Hepatology Department of the Beaujon Hospital.

A Master thesis was carried out  on the ability of Fibroscan to detect fibrosis in patient treated for HCV. It was supervised by Prof. Ahmed El Ray and Prof. Laurent Castera.

 The subject of Pancreas is approached in a constant manner by Prof.Philippe Ruszniewski at the Beaujon - Bilharz conferences. TBRI is now a reference center in Egypt for the diagnosis of Pancreas Diseases by Endosonography, the Institute has bought a second Echoendoscopy device in 2017, The first workshop in Endosonography was performed in May 2018 in the 10th Annual Scientific meeting Bilharz Beaujon.

In 2023, TBRI renewed the agreement with Beaujon hospital for the fourth time, with the inclusion of Cairo University and Paris Cité University.